SIRT1 keeps escapees quiet
نویسندگان
چکیده
منابع مشابه
Quiet Time: Gene Program Prevents Division but Keeps Cells at the Ready
March 2006 | Volume 4 | Issue 3 | e85 | e75 All organisms need defense systems to ward off infection. These defenses typically mobilize in response to antigens, bits of protein fragments derived from a pathogen. Vertebrates have a superbly effi cient system of adaptive immunity that uses proteins to recognize and bind billions of different antigens via a process known as antigen presentation. U...
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RIG-I and MDA5 are cytoplasmic RNA sensors that recognize dsRNA patterns and activate MAVS to induce innate antiviral gene program. RNA sensing is regulated by ubiquitination in RIG-I while by phosphorylation in MDA5. Thus, de novo phosphorylation is an essential step for keeping MDA5 inactive. We identified a protein kinase RIO kinase 3 (RIOK3) targeting MDA5, and here discuss its possible rel...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2009
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd3022